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An Entity of Type : skos:Concept, within Data Space : data.idref.fr associated with source document(s)

Attributes	Values
type	Concept
sameAs	http://id.nlm.nih.gov/mesh/D011384
notation	9035-68-1 D06.472.699.587.200.500 D12.644.548.586.200.500 D12.776.811.706
alternative label	Pro-insuline Proinsulin
preferred label	Proinsuline
is in scheme	http://id.nlm.nih.gov/mesh
note	A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts
is seeAlso of	http://www.idref.fr/040725995/id
is primary topic of	http://www.idref.fr/040765644
is Subject of	http://www.sudoc.fr/042120675/id http://www.sudoc.fr/144157527/id http://www.sudoc.fr/008505675/id http://www.sudoc.fr/020921829/id http://www.sudoc.fr/095357157/id http://www.sudoc.fr/246861215/id http://www.sudoc.fr/247168556/id Endoplasmic-reticulum targeting alters regulation of expression and antigen presentation of proinsulin http://www.sudoc.fr/259774081/id Tolérance à la proinsuline chez la souris

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