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An Entity of Type : skos:Concept, within Data Space : data.idref.fr associated with source document(s)

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type
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notation
  • D08.811.277.087.520.200.650
  • D08.811.913.400.725.115.961
  • D12.776.476.900
  • EC 3.5.1.-
alternative label
  • Sir2 like Proteins
  • Sir2-like Proteins
  • Sirtuins
  • Silent Mating Type Information Regulator 2-like Proteins
  • Silent Mating Type Information Regulator 2 like Proteins
  • Protéines Sir2-like
  • SIRT
  • SIRTs
  • Sirtuin
preferred label
  • Sirtuines
is in scheme
note
  • A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities
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