About: Appropriate Dose Selection — How to Optimize Clinical Drug Development

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type	frbr:Work rdac:C10001
alternative label	Appropriate dose selection - how to optimize clinical drug development
dc:subject	Medicine Chimiothérapie anticancéreuse Biochemistry Toxicology Actes de congrès Biomedicine Biochemistry, general Pharmacology/Toxicology Medicine/Public Health, general Interactions médicamenteuses Pharmacie -- Recherche
preferred label	Appropriate Dose Selection — How to Optimize Clinical Drug Development
Language	http://lexvo.org/id/iso639-3/eng
Subject	http://www.idref.fr/027221911/id http://www.idref.fr/02886431X/id http://www.idref.fr/027389391/id http://www.idref.fr/027313840/id
dc:title	Appropriate Dose Selection — How to Optimize Clinical Drug Development
Publishing director	Sittner, Wolf Venitz, Jürgen
note	Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers – based on the (known) pharmacology of the drug and/or biology of the underlying disease – along with exposure–response evaluation throughout all phases of drug development can quantitatively integrate clinical pharmacology knowledge, provide early proof of concept, and help in rational dose selection and rational drug product labeling for clinical use
dc:type	Text
http://iflastandar...bd/elements/P1001	http://iflastandards.info/ns/isbd/terms/contentform/T1009
rdaw:P10219	2007
has content type	http://rdaregistry.info/termList/RDAContentType/1020
is primary topic of	http://www.idref.fr/216277949
is rdam:P30135 of	http://www.sudoc.fr/110542037/id http://www.sudoc.fr/123153506/id

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