About: http://www.idref.fr/237513560/id

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About: http://www.idref.fr/237513560/id Goto Sponge NotDistinct Permalink

An Entity of Type : skos:Concept, within Data Space : data.idref.fr associated with source document(s)

Attributes	Values
type	Concept
seeAlso	http://www.idref.fr/199619603/id http://www.idref.fr/184182328/id
sameAs	http://id.nlm.nih.gov/mesh/D000076987
notation	EC 3.1.- D08.811.277.352.355.325.150 D12.776.097.219 D12.776.212.500
alternative label	CRISPR Associated Protein 9 CRISPR-Associated Protein 9 Cas9 Cas9 Endonuclease Cas9 Enzyme Cas9 Protein Endonuclease, Cas9 Endonucléase Cas9 Enzyme Cas9 Enzyme, Cas9 Protéine Cas9
preferred label	Protéine-9 associée à CRISPR
is in scheme	http://id.nlm.nih.gov/mesh
note	An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9
is seeAlso of	http://www.idref.fr/199619603/id http://www.idref.fr/184182328/id
is primary topic of	http://www.idref.fr/237513560
is Subject of	http://www.sudoc.fr/26429081X/id http://www.sudoc.fr/240474678/id http://www.sudoc.fr/258209526/id CRISPR-Cas Methods http://www.sudoc.fr/275272680/id http://www.sudoc.fr/274160862/id http://www.sudoc.fr/264011945/id MMEJ-mediated IDLV knock-in via CRISPR/Cas9 in human hematopoietic stem/progenitor cells. http://www.sudoc.fr/249280043/id http://www.sudoc.fr/245332049/id

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