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Subject Item
n2:id
rdf:type
frbr:Work rdac:C10001
dc:subject
Spermatozoïdes -- Anatomie pathologique Spermatogenèse -- physiologie Cytogenetics Embryologie Spermatogenèse -- Physiologie Reproduction -- immunologie Life Sciences Reproduction (biologie) -- Immunologie Human genetics Reproductive Medicine Embryology Life sciences Spermatozoïdes -- anatomopathologie
skos:prefLabel
The Male Role in Pregnancy Loss and Embryo Implantation Failure
dcterms:language
n6:eng
dcterms:subject
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dc:title
The Male Role in Pregnancy Loss and Embryo Implantation Failure
skos:note
Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors
dc:type
Text
n11:P1001
n12:T1009
rdaw:P10219
2015
rdau:P60049
n8:1020