<http://www.idref.fr/215463412/id>	<http://purl.org/dc/terms/subject>	<http://www.idref.fr/027363945/id> .
<http://www.idref.fr/215463412/id>	<http://rdaregistry.info/Elements/w/P10219>	"2012" .
<http://www.idref.fr/215463412/id>	<http://rdaregistry.info/Elements/u/P60049>	<http://rdaregistry.info/termList/RDAContentType/1020> .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/terms/language>	<http://lexvo.org/id/iso639-3/fra> .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/terms/subject>	<http://www.idref.fr/031439659/id> .
<http://www.idref.fr/215463412/id>	<http://www.w3.org/2004/02/skos/core#note>	"Ce travail a permis d\u2019\u00E9valuer la contribution et l\u2019influence des activit\u00E9s hospitali\u00E8res et d\u2019\u00E9levage sur la diss\u00E9mination de l\u2019antibior\u00E9sistance dans l\u2019environnement, au travers du suivi de la dynamique d\u2019\u00E9l\u00E9ments g\u00E9n\u00E9tiques utilis\u00E9s comme biomarqueurs de l\u2019antibior\u00E9sistance : les int\u00E9grons de r\u00E9sistance (IR). Ainsi, de nombreux r\u00E9sidus biologiques solides et liquides d\u2019origines anthropiques et g\u00E9ographiques diverses peuvent participer \u00E0 la diss\u00E9mination de l\u2019antibior\u00E9sistance. Les effluents hospitaliers pr\u00E9sentent des proportions plus \u00E9lev\u00E9es d\u2019IR, et contribuent \u00E0 l\u2019apport de 14% des IR arrivant dans les stations d\u2019\u00E9puration municipales, n\u00E9anmoins les effluents urbains repr\u00E9sentent la fraction majoritaire. La caract\u00E9risation des cassettes de g\u00E8nes de r\u00E9sistance h\u00E9berg\u00E9es par ces IR, a mis \u00E0 jour des g\u00E8nes de r\u00E9sistance bien sp\u00E9cifiques dans les effluents hospitaliers, alors que les effluents urbains participent \u00E0 l\u2019apport d\u2019une plus grande diversit\u00E9 de g\u00E8nes dont des g\u00E8nes codant pour des r\u00E9sistances multiples (BLSE). Les proc\u00E9d\u00E9s de traitement actuels \u00E9liminent une fraction des IR mais n\u2019emp\u00EAchent pas des IR d\u2019origine anthropique de rejoindre l\u2019environnement. De plus, une \u00E9tude pilote a r\u00E9v\u00E9l\u00E9 que le traitement des effluents hospitaliers par ces proc\u00E9d\u00E9s \u00E0 boues activ\u00E9es induit une augmentation des IR et de bact\u00E9ries potentiellement pathog\u00E8nes au sein des boues d\u2019\u00E9puration, soulevant la probl\u00E9matique de la diss\u00E9mination de l\u2019antibior\u00E9sistance au sein de ces matrices. Finalement la mise en exergue de ce biomarqueur pour \u00E9valuer des proc\u00E9d\u00E9s de traitement avanc\u00E9s des effluents hospitaliers (bior\u00E9acteur membranaires, ozonation, charbon actif), a montr\u00E9 l\u2019efficacit\u00E9 des bior\u00E9acteurs membranaires par ultrafiltration pour r\u00E9duire \u00E0 la fois les bact\u00E9ries et les IR d\u2019origine anthropique." .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/terms/subject>	<http://www.idref.fr/027772616/id> .
<http://www.idref.fr/215463412/id>	<http://id.loc.gov/vocabulary/relators/dgg>	<http://www.idref.fr/026403315/id> .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/terms/subject>	<http://www.idref.fr/027253139/id> .
<http://www.idref.fr/215463412/id>	<http://www.w3.org/1999/02/22-rdf-syntax-ns#type>	<http://rdaregistry.info/Elements/c/C10001> .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/elements/1.1/subject>	"Th\u00E8ses et \u00E9crits acad\u00E9miques" .
<http://www.idref.fr/215463412/id>	<http://www.w3.org/1999/02/22-rdf-syntax-ns#type>	<http://purl.org/vocab/frbr/core#Work> .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/elements/1.1/subject>	"D\u00E9chets -- \u00C9limination" .
<http://www.idref.fr/215463412/id>	<http://www.w3.org/2004/02/skos/core#prefLabel>	"Implication des effluents d'activit\u00E9s hospitali\u00E8res et de la fili\u00E8re carn\u00E9e sur la diss\u00E9mination de l\u2019antibior\u00E9sistance, Dynamique des int\u00E9grons de l\u2019\u00E9mission au rejet" .
<http://www.idref.fr/215463412/id>	<http://iflastandards.info/ns/isbd/elements/P1001>	<http://iflastandards.info/ns/isbd/terms/contentform/T1009> .
<http://www.idref.fr/215463412/id>	<http://id.loc.gov/vocabulary/relators/ths>	<http://www.idref.fr/059358041/id> .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/elements/1.1/title>	"Implication des effluents d'activit\u00E9s hospitali\u00E8res et de la fili\u00E8re carn\u00E9e sur la diss\u00E9mination de l\u2019antibior\u00E9sistance, Dynamique des int\u00E9grons de l\u2019\u00E9mission au rejet" .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/elements/1.1/subject>	"D\u00E9chets biom\u00E9dicaux" .
<http://www.idref.fr/215463412/id>	<http://www.w3.org/2004/02/skos/core#note>	"This work aims to assess the global contribution and influence of hospital activities and livestock industries on the dissemination of antibiotic resistance in the environment. For this purpose, the dynamics of a genetic element used as a biomarker of antibiotic resistance, the resistance integrons (RI), was monitored. Indeed, a wide range of solids and liquids biological wastes from different geographical and anthropogenic origins are involved in the antibiotic resistance dissemination. However, we showed that hospital effluents contained a high proportion of RIs in bacterial communities, and the gene cassette (GC) content of class 1 RI mainly showed antibiotic resistance GCs. Hospital effluent contributed to 14% of the Ris introduced in the waste water treatment plant (WWTP). While urban effluents diluted the risk associated with hospital effluent, RIs harboring GCs of clinical interest, such as ESBLencoding GCs, were found in these effluents unaffected by medical and industrial activities. The WWTP did not reduce the proportion of RIs in treated effluents but eliminated a fraction of the bulk of GCs from the influent. Large quantities of RIs harboring antibiotic-resistance GCs, and also GCs with unknown functions were released daily into the environment. In addition, a pilot study showed that the treatment of hospital wastewater by the activated sludge process promoted the increase of IR and potentially pathogenic bacteria in the sewage sludge, and consequently increased the issue of antibiotic- resistance spread in these matrices. Finally the use of RI as biomarker to assess the efficiency of advanced treatment processes for hospital effluents (membrane bioreactor ozonation, activated carbon) highlighted the effectiveness of membrane bioreactors using ultrafiltration to reduce both bacteria and IR of anthropogenic origins." .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/elements/1.1/subject>	"\u00C9levage -- Sous-produits" .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/elements/1.1/subject>	"R\u00E9sistance aux antibiotiques -- Diss\u00E9mination -- Environnement" .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/elements/1.1/subject>	"int\u00E9grons de r\u00E9sistance" .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/terms/subject>	<http://www.idref.fr/053498836/id> .
<http://www.idref.fr/215463412/id>	<http://id.loc.gov/vocabulary/relators/aut>	<http://www.idref.fr/170558436/id> .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/elements/1.1/type>	"Text" .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/terms/subject>	<http://www.idref.fr/031185231/id> .
<http://www.idref.fr/215463412/id>	<http://www.w3.org/2004/02/skos/core#altLabel>	"Involvement of the hospital effluents and the meat industry on the spread of antibiotic resistance, Dynamic of the integrons from the source to the release" .
<http://www.idref.fr/215463412/id>	<http://purl.org/dc/terms/subject>	<http://www.idref.fr/027426211/id> .
<http://www.idref.fr/215463412/id>	<http://id.loc.gov/vocabulary/relators/ths>	<http://www.idref.fr/057866171/id> .
<http://www.idref.fr/215463412/id>	<http://id.loc.gov/vocabulary/relators/ths>	<http://www.idref.fr/033641781/id> .