"Th\u00E8ses et \u00E9crits acad\u00E9miques" . . "Bases mol\u00E9culaires de la liaison des mycobact\u00E9ries au r\u00E9cepteur DC-SIGN" . "Cellules dendritiques" . "M. tuberculosis binds to dendritic cells through a C-type lectin (DC-SIGN: dendritic cell-specific ICAM-3 Grabbing Non integrin). Previous studies suggested that DC-SIGN differentially binds to the pathogenic M. tuberculosis and the non-pathogenic M. smegmatis. This feature has been tentatively attributed to differencies in the LAM cap structures. During my thesis, we enlarged this finding by showing that DC-SIGN is able to discriminate M. tuberculosis complex species from others species whatever their pathogenic status. Furthermore, we showed that this differential binding cannot be associated to LAM cap structures or localization, but rather to the presence of other potential ligands including glycoproteins. Thus the binding between DC-SIGN and the M. tuberculosis complex species appears to de more complicated then previously suspected and seems to be due to cooperative interaction of DC-SIGN with several ligands." . "Bases mol\u00E9culaires de la liaison des mycobact\u00E9ries au r\u00E9cepteur DC-SIGN" . "2006" . "M. tuberculosis se lie aux cellules dendritiques par l'interm\u00E9diaire d'une lectine de type C (DC-SIGN). Des \u00E9tudes ant\u00E9rieures ont sugg\u00E9r\u00E9 que DC-SIGN puisse diff\u00E9rencier une esp\u00E8ce mycobact\u00E9rienne pathog\u00E8ne M. tuberculosis d'une esp\u00E8ce non pathog\u00E8ne M. smegmatis. Ce ph\u00E9nom\u00E8ne semblait \u00EAtre attribu\u00E9 \u00E0 une structure particuli\u00E8re des coiffes mannosyl\u00E9es du lipoarabinomannane (ManLAM). Durant ma th\u00E8se, nous avons montr\u00E9 que DC-SIGN est capable de diff\u00E9rencier les esp\u00E8ces appartenant au complexe tuberculosis des autres esp\u00E8ces. Cependant, nos r\u00E9sultats indiquent que la discrimination par DC-SIGN n'est pas due \u00E0 une structure particuli\u00E8re des coiffes ou \u00E0 la localisation du ManLAM, et que d'autres ligands pourraient intervenir dans la liaison, telles que les glycoprot\u00E9ines. Ainsi, la liaison entre DC-SIGN et les esp\u00E8ces du complexe tuberculosis semble plus compliqu\u00E9 que se que l'on avait imagin\u00E9 et r\u00E9sulterait de la liaison coop\u00E9rative de plusieurs ligands." . "Text" . "R\u00E9ponse immunitaire" . . . "Molecular bases of the connection of mycobacterial binding to the DC-SIGN receptor" . . "Lipoarabinomannane" . "Mycobact\u00E9rie" . "DC-SIGN" . . . "Mycobacterium tuberculosis -- G\u00E9n\u00E9tique mol\u00E9culaire" . . . . . . "Tuberculose" . . . "Lectines" . . . "Complexes r\u00E9cepteur-ligand" . .